ETA recently submitted a Letter to the Editor of Food and Chemical Toxicology to address an article in its July publication, “GRAS from the ground up: Review of the Interim Pilot Program for GRAS notification” by Hanlon et al., 2017. The ETA letter clarifies and expands upon points highlighted by Hanlon et al. regarding the common knowledge element of the safety of food enzymes used to support the generally recognized as safe (GRAS) designation. The letter outlines a peer-reviewed, generally recognized safety evaluation methodology for microbial enzymes, which provides the US FDA with a review framework for enzyme GRAS Notices. This approach may serve as a model to other food ingredient categories for a scientifically sound, rigorous, and transparent application of the GRAS concept.

Read the response here.
Journal: Food and Chemical Toxicology,